Dana-Farber Cancer Institute
Boston, MA, USA
Job Ref:JR-1849
Location:450 Brookline Ave,
BOSTON,
MA 02215
Category:Research Laboratory
Employment Type:Full time
Work Location:Onsite: 100% onsite
Salary/Pay Rate:$47,500.00 - $51,300.00 per year
Overview
The Polizzi lab uses a mix of computational and experimental approaches to design and characterize ligand-binding proteins. We develop machine-learning techniques to compute the structures and sequences of proteins that bind to challenging small-molecule ligands. We then express these proteins in the lab and characterize them with biophysical and structural methods (see, e.g., Ashworth, Polizzi & DeGrado, Science 2024). We aim not only to unlock the design principles used by proteins for molecular recognition but also to make useful proteins for probing and manipulating biology. By designing de novo small-molecule-binding proteins, we can isolate the essential ingredients for protein molecular recognition events, obtain atomic-level control...
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Research
Technician
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