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The Pe ndergast lab inthe Department of Pharmacology and Cancer Biology, Duke U niversity School ofMedicine is seeking to recruit a postdoctoral positio n to study the role oftyrosine kinase networks in the regulation of rege neration and repair followinginjury to the lung epithelium. Damage to th e lung epithelium by respiratoryinfections is associated with respirator y failure and induction of acuterespiratory distress syndrome which has an incidence of about 200,000 cases inthe United States each year and is associated with a high mortality rate. Currentlylittle is known regardi ng the identity of signaling networks that might beeffectively targeted to promote recovery from lung injury. We recently reportedthat genetic i nactivation of Abl1specifically in a subset of lung epithelial cells resulted in marked expansionof a progenitor cell population leadin g to alveolar regeneration followingbacterial pneumonia. Importantly, we found that treatment with ABL kinase specificinhibitors enhanced regene ration of the alveolar epithelium and promotedaccelerated recovery of mi ce following pneumonia. These and ongoing studies usingstate of the art technologies (single-cell RNA-seq, Spatial Transcriptomics,etc.) seek to develop new therapeutic strategies to treat lung injury induced bypatho gens and toxic agents (Khatri, et al 2019; Proc. Natl. Acad. Sci. US A 116: 1603-1612). We offer an inspiringintellectual, collaborative and multidisciplinary research environment tosupport your career goals and provide access to state-of-the-art facilities.
Candidates who are highly motivate d and share a vision of excellence and commitment to research witha recent Ph.D. in developmental biology, regenerative medicine, and/o r tumor biology using mouse models are preferred. Candidates sh ould have a strong inner drive, independence, and willingness to work in a highly interdisciplinary team. Candidates with demonstrated expertise in lung epithelial biology and interest on the study of regeneration an d repair pathways are encouraged to apply.
Candidates must be leg ally authorized to work in the US. Applications will be reviewed until p ositions are filled. The positions are available immediately.
How to Apply:
Please send C.V. and the names and e-m ail addresses of three references to:
Con tact Name:
Ann Marie Pendergast, Ph.D.
Anthony R. M eans Cancer Biology Professor
Vice Chair, Department of Pharmacolo gy and Cancer Biology
Director of Graduate Studies, Molecular Cancer Biology
Contact Email:< /p>
See job description for education requirements.
See job description for requirements.
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