School of Medicine:
Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.
Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
The Duke Brain Tumor Immunotherapy Program (BTIP) has a singular, all-encompassing goal: to develop novel, safe, and effective immune-based therapies for patients with brain tumors. Our preclinical and clinical projects are spearheaded by an outstanding complement of graduate students, medical students, residents, postdoctoral fellows, and junior and senior scientists assembled under the umbrella of the Duke BTIP.
Position is 100% grant-funded.
Provide leadership and expertise in conducting complex research activities with the objective of developing and evaluating immunotherapies targeted at eliminating brain tumors. Job responsibilities will include planning, organizing and conducting experiments with human and murine samples and will also include the evaluation of in vivo murine models. This individual will be expected to independently analyze and present experimental findings as well as present detailed protocols for the next potential experimental steps. This individual will need to be experienced with managing and prioritizing multiple projects simultaneously with time-sensitive objectives and maintaining up to date and proper notebook documentation of all experiments. Previous experience with immunology would be highly valued. • Experimental work may include the following techniques: tissue-culture with sterile technique, DNA derivation, cDNA derivation, RNA production, cloning of DNA vectors, retroviral production, PCR, qPCR, western blots, ELISA, ELISpot, and flow-cytometry. For in vivo mouse models, work may include intradermal, intraperitoneal, subcutaneous and intravenous injection of mice, intracranial and subcutaneous tumor models, survival analyses, as well as isolation of blood, spleen, bone marrow, brain and lymph nodes and the isolation of cells residing in those tissues. • Establish and follow standard operating procedures. • Train other laboratory personnel in experimental techniques as needed. • Confer with faculty in developing plans for research projects and to discuss the interpretation of results and the preparation of manuscripts for publication. • Work will use MS Office (PowerPoint, Word, Excel, Outlook), FlowJo, DIVA and GraphPad Prism software. • Perform other related duties incidental to the work described herein.
The above statements describe the general nature and level of work being performed by individuals assigned to this classification. This is not intended to be an exhaustive list of all responsibilities and duties required of personnel so classified.
Strongly Preferred Qualifications at this Level
A Master's degree is strongly preferred. Applicant must have previous laboratory experience, experience with mouse models, immune assays, and tissue culture. Five years of experience in research/data analysis or related position.
Work requires a bachelor's degree in botany, biology, zoology, psychology or other directly related scientific field.
Work requires four years of research experience. A related master's OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE degree may offset required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience.
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Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.