- Location: Durham, NC
- Posted: Jan 15, 2020
School of Medicine:
Established in 1930, Duke University School of Medicine is the youngest of the nations top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.
Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
The Department of Surgery seeks a highly-motivated postdoctoral associate to perform independent basic research within the Urinary Dysfunction Laboratory in the Department of Surgery/Division of Urology. The laboratory PI is Dr. Todd Purves, an MD/PhD board-certifiedphysician in pediatric urology. The lab manager is Dr. Monty Hughes, a Ph.D with 25+ years experience running a basic research lab. The goal of the lab is to better understand the role of inflammation in bringing about pathological conditions associated with benign urological disease. We have primarily been focused on the NLRP3 inflammasome in this process. We are particularly interested in how bladder-associated damage is sensed and how the resulting inflammatory response is translated into the urinary dysfunction and cellular/molecular changes that characterize disease. Currently we are actively investigating NLRP3 in bladder outlet obstruction models (which reflect the obstruction created bybenign prostatic hyperplasia in older men) and diabetes. For these studies the laboratory takes a comprehensive approach ranging from physiological measurements to numerous cellular and molecular assays. Requirements: We are seeking highly motivated, recent Ph.D. Degree in a physiology/cell biology/biochemistry field. Experience in the lower urinary tract would be considered a positive. Please submit a cover letter, curriculum vitae, and contact information for three references. Min Degree Requirements: Ph.D. or equivalent doctorate (e.g. Sc.D., M.D., D.V.M.). If the candidate has completed all of the requirements for a degree, but the degree has not been formally conferred; the candidate may present evidence of completion of the degree requirements, together with a statement documenting the date on which the degree isto be conferred. Other Credential/Experiential Requirements: Extensive experience in rodent handling and experimentation Expertise in laboratory techniques related to molecular biology, biochemistry, cell signaling and physiology research is essential. Ability to analyze, interpret and present experimental results. Previous publications in top-tier peer-reviewed publications is expected and grant writing experience is a positive Excellent verbal and written communication skills in English with good organizational and analytical abilities Capable of working independently and trouble-shooting experiments is required and will be fostered in this position. Development of independent ideas and projects is also highlyencouraged, particularly in the later stages of this appointment. However, the candidate must also work well in a team-based environment and be able to activelyparticipate in multi-disciplinary collaborations.
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