Laboratory Manager


  • Location: Boston, MA
  • Posted: Sep 16, 2019

Job Description


The Laboratory Manager/Research technician position will work closely with the Principal Investigator (PI) who directs the Boston Medical Center Infectious Disease Clinical Research Unit (CRU) where many patient-oriented HIV clinical studies are being conducted. The PI runs a HIV translational research program and this position is to be the laboratory component of the Clinical research infrastructure. The overall research program of the PI is to understand the effects of coinfections and lifestyle factors, such as smoking, drug use, aging, specific treatments, on the immune system of HIV infected people and the HIV latent reservoir.

Laboratory responsibilities include handling and processing human specimens (PBMC isolation, lung and other tissue sample processing, cell DNA and RNA isolation) from ongoing clinical trials, coordinating shipment and storage and keeping inventory of the growing sample repository from participants in clinical studies. The position also will be responsible for implementing and following standard operating procedures in accordance with all applicable regulations in the protocol and to prepare for study monitor visits.

The PIs laboratory research program is multidisciplinary and will involve working with various scientific collaborators, as well as coordinating sample collection with clinicians enrolling study participants. The research portion of the job will involve analyses of HIV latent reservoir, low level viremia using optimized real-time PCR assays. Lab work will also involve making recombinant HIV viruses, cell cultures and doing ELISA assays to measure various immunological markers. Some sequencing work using novel sequencing technologies to profile transcriptional signatures of isolated cell populations are expected in the near future, and further training for this will be provided.

The Laboratory Manager/Research technician position will also oversee and coordinate the laboratorys daily operations, train and mentor lab personnel and ensure compliance with safety and regulatory standards. The ideal candidate will be motivated, possess strong communication and management skills, and have outstanding laboratory experience and ability. Prior experience in the conduct of patient-oriented studies and laboratory management experience preferred.

This position functions as a critical part of the clinical research team (Infectious Disease Clinical Research Unit) and provides ample opportunities to mentor and train, develop new skills, and communicate results to the scientific community through conference presentations and peer reviewed publications in a supportive, highly collaborative, and energetic environment within an exceptional research setting with state-of-the-art facilities.

POSITION SUMMARY:

The Laboratory Manager/Research technician position will work closely with the Principal Investigator (PI) who directs the Boston Medical Center Infectious Disease Clinical Research Unit (CRU) where many patient-oriented HIV clinical studies are being conducted. The PI runs a HIV translational research program and this position is to be the laboratory component of the Clinical research infrastructure. The overall research program of the PI is to understand the effects of coinfections and lifestyle factors, such as smoking, drug use, aging, specific treatments, on the immune system of HIV infected people and the HIV latent reservoir.

Laboratory responsibilities include handling and processing human specimens (PBMC isolation, lung and other tissue sample processing, cell DNA and RNA isolation) from ongoing clinical trials, coordinating shipment and storage and keeping inventory of the growing sample repository from participants in clinical studies. The position also will be responsible for implementing and following standard operating procedures in accordance with all applicable regulations in the protocol and to prepare for study monitor visits.

The PIs laboratory research program is multidisciplinary and will involve working with various scientific collaborators, as well as coordinating sample collection with clinicians enrolling study participants. The research portion of the job will involve analyses of HIV latent reservoir, low level viremia using optimized real-time PCR assays. Lab work will also involve making recombinant HIV viruses, cell cultures and doing ELISA assays to measure various immunological markers. Some sequencing work using novel sequencing technologies to profile transcriptional signatures of isolated cell populations are expected in the near future, and further training for this will be provided.

The Laboratory Manager/Research technician position will also oversee and coordinate the laboratorys daily operations, train and mentor lab personnel and ensure compliance with safety and regulatory standards. The ideal candidate will be motivated, possess strong communication and management skills, and have outstanding laboratory experience and ability. Prior experience in the conduct of patient-oriented studies and laboratory management experience preferred.

This position functions as a critical part of the clinical research team (Infectious Disease Clinical Research Unit) and provides ample opportunities to mentor and train, develop new skills, and communicate results to the scientific community through conference presentations and peer reviewed publications in a supportive, highly collaborative, and energetic environment within an exceptional research setting with state-of-the-art facilities.

ESSENTIAL RESPONSIBILITIES / DUTIES:

Under the direction of the Principal Investigator, the Lab Manager independently carries out daily activities of the laboratory, including:

Processing clinical samples for extraction of RNA and DNA, preparation of sequencing libraries, and use of a variety of next generation sequencing platforms.
Administrate day-to-day operations in the lab, including personnel training, organization, and work-flow optimization.
Maintain specimens inventory and repository in accordance with processing laboratory established procedures.
Testing and shipping specimens from participants in clinical studies when necessary.
Ensuring quality control of equipment, reagents and extensive biological specimens.
Working closely within the HIV virology lab group, Clinical research unit staff and with outside collaborators.
Implements and follow standard operating procedures in accordance with all applicable regulations.
Maintains reagent s inventory and assists in scheduling of equipment maintenance.
May coordinate all (or portion) of research study activities. Function as a resource for all study issues. Identifies problems and develops solutions.
Responsible for overseeing the laboratory data collection process. Ensures integrity of participants data.
Implements and maintains quality assurance procedures and systems.
In collaboration with PI, assists in the implementation of new research protocols including design, data collection systems.
In collaboration with PI, prepares and may present certain portions of presentations, in addition to preparing articles for publication.
May be responsible to monitor grant budget, in collaboration with laboratory supervisor, PI or Project Coordinator.

Must adhere to all of BMCs RESPECT behavioral standards.

(The above statements in this job description are intended to depict the general nature and level of work assigned to the employee(s) in this job. The above is not intended to represent an exhaustive list of accountable duties and responsibilities required).

JOB REQUIREMENTS

EDUCATION:

Bachelors' degree required. MS/MPH/PhD degree in a science is strongly preferred.

CERTIFICATES, LICENSES, REGISTRATIONS REQUIRED:

N/A

EXPERIENCE:

Must have a minimum of 3-5 years of experience in laboratory research, with strong preference to candidates with previous experience working in patient-oriented studies. Laboratory management experience preferred.

Laboratory experience required, especially a background in cell culture, real-time PCR and molecular assays. Some next-generation sequencing and immunology experience will be ideal.

Flexibility to occasionally work evenings or early mornings to coordinate patient study visit where specimens are collected.

Computer experience is essential

Some experience in managing and organizing specimen database from clinical studies is advantageous.

KNOWLEDGE AND SKILLS:

Highly independent and motivated, with the ability to work in a dynamic team environment

Excellent organizational skills and attention to detail

Minimum 3 year commitment

Employment Type


  • Full time

Boston Medical Center

840 Harrison Ave
Boston, MA 02118

Opened: 1855

Web: http://jobs.bmc.org

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